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鄭粲煌

教師一覽表

鄭粲煌

學歷

高雄醫學大學藥學研究所博士

經歷

  1. 2002.8~2003.2：台灣派頓製藥股份有限公司研發部經理
  2. 2003.3~2003.9：國立成功大學生物科技研究所博士後研究員
  3. 2003.9~2004.7：聯群生技有限公司實驗室主管
  4. 2003.2~2004.7：中華醫事學院生物科技系兼任助理教授
  5. 2004.8~2009.8：中華醫事科技大學實驗中心主任
  6. 2004.8~2015.7：中華醫事科技大學生物科技系專任助理教授
  7. 2009.9~2015.6：中華醫事科技大學總務長
  8. 2015.8~2016.7：中華醫事科技大學食品營養系專任助理教授
  9. 2017.8~至今  ：中華醫事科技大學製劑製造工程系專任副教授
  10. 2017.8~至今  ：中華醫事科技大學總務長

專長與教授課程

化學相關領域專長

分析化學、儀器分析、有機化學

認證相關領域專長

ISO17025、ISO9001

證照

  1. 實驗室認證標準ISO/IEC 17025訓練合格
  2. TAF測試實驗室負責人訓練合格
  3. 能源管理人員訓練合格
  4. 採購專業人員基礎訓練及格
  5. ISO 9001主導稽核員
  6. 丙級職業安全衛生業務主管

執行計畫

  1. 主題：中藥有害物質檢驗技術平台之研究與開發，合作機構：中醫藥委員會2006.1.1-2007-12.31。
  2. 主題：中藥材農藥殘留檢驗技術之開發，合作機構：教育部2008.1.1~2008.12.31。
  3. 主題： 含藥化妝品處方設計(I)，合作機構：聯群生技有限公司，2008.1.1~2010.12.31年。
  4. 主題： 學界協助中小企業科技關懷計畫，合作機構：金屬工業研究發展中心2009.7.1~2009.12.31。
  5. 主題：功能性化妝品開發之研究，合作機構：皇羿有限公司，2018.1.1~2018.12.31。
  6. 主題：從生物指標驗證不同舒壓策略對青少年之壓力舒緩效果探討，合作機構：中華醫事科技大學，2018.4.1~2018.10.31。

發表著作

期刊論文

  1. Chen YH, Tsai JC, Cheng TH, Yuan SS, Wang YM (2014) Sensitivity evaluation of NBD-SCN towards cysteine/homocysteine and its bioimaging applications. Biosensors and Bioelectronics 56:117-123.
  2. SCI Impact Factor: 6.409；Ranking:7/73=9.59%, Q1, Biophysics
  3. Lee YC, Cheng TH, Lee JS, Chen JH, Liao YC, Fong Y, Wu CH, Shih YW (2011) Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. Mol Cell Biochem 347:103–115.
  4. SCI Impact Factor: 2.057；Ranking:126/184=68.48%, Q3, Cell Biology
  5. Shieh JM, Cheng TH, Shi MD, Wu PF, Chen Y, Ko SC, Shih YW (2011) -Tomatine Suppresses Invasion and Migration of Human Non-Small Cell Lung Cancer NCI-H460 Cells Through Inactivating FAK/PI3K/Akt Signaling Pathway and Reducing Binding Activity of NFB. Cell Biochem Biophys 60(3):297-310.
  6. SCI Impact Factor: 3.743；Ranking:18/74=24.32%, Q1, Biophisics
  7. Chen TJ, Cheng TH, Chen CY, Hsu Sodio CN, Cheng TL, Liu GC, WangYM* (2009) Targeted Herceptin–dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI. J Biol Inorg Chem 14:253–260.
  8. SCI Impact Factor: 3.433；Ranking:11/44=25.0%, Q1, Chemistry, Inorganic & Nuclear
  9. Chen TJ, Cheng TH, Hung YC, Lin KT, Liu GC, YM Wang (2008) Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI. Journal of Biomedical Materials Research Part A 87:165-175.
  10. SCI Impact Factor: 2.873: Ranking:11/72=15.28%, Q1, Engineering, Biomedical
  11. Cheng TH, Lee WT, Jeng JS, Wu CM, Liu GC, Chiang Michael YNan, Wang YM* (2006) Synthesis and characterization of a novel paramagnetic macromolecular complex [Gd(TTDASQ–protamine)]. Dalton Transactions 43:5149-5155. (SCI Impact Factor: 3.003)
  12. Ou MH, Cheng TH, Liu GC, Wang YM* (2005) Physicochemical Characterization of Four Gadolinium(III) DTPA-like Complexes. J Chin Chem Soc 52: 895-906. (SCI Impact Factor: 0.617)
  13. Lee TM, Cheng TH, Liu GC, Wang YM* (2004) Physicochemical characterization of the dimeric lanthanide complexes [enfLn(DO3A)(H2O)g2] and [pifLn(DTTA)(H2O)g2]2.: a variable-temperature 17O NMR study. Magn Reson Chem 42:329-336. (SCI Impact Factor: 1.553)
  14. Cheng TH, Lee TM, Ou MH, Li CR, Liu G.C, Wang YM* (2002) Thermodynamic Stability and Physicochemical Characterization of Ligand (S)-4-benzyl-3,6,10-tri(carboxymethyl)-3,6,10-triazadode- canedioic Acid and Its Complexes Formed with Lanthanide, Ca2+, Zn2+, and Cu2+ Ions. Helv Chim Acta 85:1033-1050. (SCI Impact Factor: 1.650)
  15. Sheu RS, Wang YM, Kuo YT, Cheng TH, Jaw TS, Liu GC* (2002) [Gd(DTPA-BDMA)] as a Magnetic Resonance Contrast Agent: Acute Toxicity Test and Preliminary Images. Kaohsiung J Med Sci 18(2):77-83.
  16. Cheng TH, Wang YM*, Lin KT, Liu G.C (2001) Synthesis of four derivatives of 3, 6,10-tri(carboxymethyl)-3, 6, 10- triazadodecanedioic acid, the stabilities of their complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) and water-exchange investigations of Gd(III) chelates. J Chem Soc Dalton Trans 3357-3366. (SCI Impact Factor: 3.003)
  17. Cheng TH, Lin KT, Ou MH, Shih HL, Liu G.C, Wang YM* (2001) Water-exchange and relaxometric studies of Gd(III) complexes with DTPA-bis(amide) ligands. J Chin Chem Soc 48: 1099-1105. (SCI Impact Factor: 0.617)
  18. Wang YM*, Cheng TH, Liu G.C (2000) Synthesis of two derivatives of 3,6,9-tri(carboxymethyl)-3,6,9-triazaundecanedioic acid and the stabilities of their complexes with Ca2+, Cu2+, Zn2+, Dy3+ and Gd3+. J Chin Chem Soc 47:1083-1094. (SCI Impact Factor: 0.617)
  19. Cheng TH, Wang YM*, Lee WT, Liu G.C (2000) Synthesis of two N’-2-pyridylmethyl and N’-2-hydroxypropyl derivatives of diethylenetriamine pentaacetic acid and the stabilities of their complexes with Ln3+, Ca2+, Cu2+ and Zn2+. Polyhedron 19:2027-2037. (SCI Impact Factor: 1.957)
  20. Wang YM*, Cheng TH, Liu GC, Sheu RS (1997) Synthesis of some N,N-bis(amide) derivatives of diethylenetriaminepentaacetic acid and the stabilities of their complexes with Gd3+, Ca2+, Cu2+ and Zn2+. J Chem Soc Dalton Trans 833-837. (SCI Impact Factor: 3.003)
  21. Wang YM*, Cheng TH, Sheu RS, Chen IT, Chiang MY (1997) Relaxivity Study and X-ray Structure of Gd(III)-diethylenetriamine-N,N’,N”-triacetic- N,N”-bis(benzylamide). A Potential MRI Contrast Agent. J Chin Chem Soc 44:123-128. (SCI Impact Factor: 0.617)

研討會論文

  1. Y. M Wang, T. H. Cheng, W. T. Lee and G. C. Liu,, Synthesis, thermodynamic and NMR studies for the complexation of Gd3+ by DTPA-PY and DTPA-HP as contrast agents for MRI, Presented at Global Chinese Synposium on Biomaterials and Control Release, Taipei, Taiwan, R.O.C., Oct. 27-28, 1999.
  2. T. H. Cheng, W. T. Lee, T. M. Lee and Y. M. Wang, Synthesis, Thermodynamic and Relaxivity Studies for the Complexation of Gd3+ by PY-DTPA and HP-DTPA as Contrast Agents for MRI, Presented at Synposium on the 8th Asian Chemical Congress, Taipei, Taiwan, R. O. C. Nov. 21-24, 1999.
  3. T. H. Cheng, C. H. Lee, H. L. Shih and Y. M. Wang, Alkaline earth metal and lanthanide(III) complexes of ligands based upon the two derivatives of 3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid, Presented at Synposium on the Annual Meeting of Chinese Chemical Society, Taipei, Taiwan, R.O.C., Nov. 19-21, 1999.
  4. T. H. Cheng, M. H. Ou, and H. L. Shih and Y. M. Wang, Synthesis, thermodynamic and Relaxivity studies by [Gd(DTPA-PY)] and [Gd(DTPA-HP)] as contrast agents for MRI, Presented at Synposium on the Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan, R.O.C., Dec. 18, 1999.
  5. Y. M. Wang, G. C. Liu, T. H. Cheng, R. S. Sheu, Synthesis and Characterization of New Contrast Agents for MRI, Presented at Symposium on the workshop on MR Imaging and Contrast Agent for Diagnosis of Hepatic Disease, Lun-Tan, Taiwan, March. 16, 2000.
  6. Y. M. Wang, T. H. Cheng, G. C. Liu, Synthesis, Thermodynamic and Relaxivity Studies for the Complexation of Gd3+ by TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P as Contrast Agents for MRI, Presented at the 2000 Symposium on isotope and radiation application, Lun-Tan, Taiwan, May,. 18-20, 2000.
  7. Y. M. Wang, C. A. Chang, T. H. Cheng and H. L. Shih, Synthesis and Characterization for the Complexation of Gd(III) by EN(DO3A)2 and AP-DO3A as Contrast Agent for MRI, Presented at the 2000 Symposium on isotope and radiation application, Lun-Tan, Taiwan, May,. 18-20, 2000.
  8. Y. M. Wang, T. H. Cheng and G. C. Liu, Synthesis and Characterization of Gd(III) Complexes with Polyaminocarboxylates as Contrast Agents for MRI, Presented at Symposium on the 6th Biomedical Material and Technology Symposium, Taipei, Taiwan, June. 3-4, 2000.
  9. Y. M. Wang and T. H. Cheng, Synthesis, Thermodynamic and Relaxivity Studies for the Complexation of Gd3+ by TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P, Presented at Symposium on the 19th IUPAC International Conference Organometallic Chemistry, Shanghai, China, July. 23-28, 2000.
  10. T. H. Cheng, and Y. M. Wang, Synthesis of Two New derivatives of 3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid and the Stabilities of Their Complexes with Gd3+, Ca2+, Cu2+ and Zn2+, 3rd World-wide Symposium on Inorganic Chemistry for Chinese Scientists, Academia Sinica, Taipei, August 1-4, 2000.
  11. T. H. Cheng, C. H. Lee, C. Y. Chen and Y. M. Wang, Gd(III), Ca(II), Cu(II) and Zn(II) complexes of ligands based upon the four derivatives of 3,6,10-tri(carboxy methyl)-3,6,10-triazadodecanedioic acid, Synposium on the Annual Meeting of Chinese Chemical Society, Tai-Chung, Taiwan, R.O.C., Nov. 25-26, 2000.
  12. Y. M. Wang and T. H. Cheng, Synthesis of four derivatives of 3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid and the stabilities of their complexes with Gd(III), Ca(II), Cu(II) and Zn(II), Presented at Synposium on the Annual Meeting of Pacifiche 2000, Hawaii, USA, Dec. 14-19, 2000.
  13. Y. M. Wang, T. H. Cheng, G. C. Liu, R. S. Sheu, T. S. Jaw, Synthesis, Thermodynamic and Relaxivity Studies for the Complexation of Gd3+ by TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P as Contrast Agents for MRI, Presented at Synposium on the Joint Annual Meeting of 9th International society for magnetic resonance in medicine and 18th European society of magnetic resonance in medicine and biology, Glasgow, UK, April 21-27, 2001.
  14. Y. M. Wang, T. H. Cheng and K. T. Lin, Synthesis, thermodynamic, water-exchange and relaxivity studies for the complexation of Gd3+ by TTDA derivatives as contrast agents for MRI, Presented at Synposium on the Denmark-Taiwan biological inorganic chemistry, Taipei, Taiwan, May 21-22, 2001.
  15. T. H. Cheng and Y. M. Wang, Synthesis and Characterization of the Ligands TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P and Their Ln(III) Complexes, Presented at Synposium on the Annual Meeting of Chinese Chemical Society, Tainan, Taiwan, R.O.C., Dec. 28-30, 2001.
  16. Y. M. Wang, T. H. Cheng, T. M. Lee and G. C. Liu, Synthesis, Thermodynamic Stability and Physicochemical Characterization of Ligand (S)-4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazadodecanedioic Acid ([Gd((S)-4-Bz-TTDA)]2) and Its Gd(III) Complex as Contrast Agent for MRI, Presented at Synposium on the 19th European society of magnetic resonance in medicine and biology, Cannes, France, Aug. 22-25, 2002.
  17. Y. M. Wang, T. H. Cheng, S. C. Tsai, G. C. Liu and R. S. Sheu, Transmetallation and Relaxometric Evaluation of Manganese(II) Complexes for Application as Contrast Agents for Magnetic Resonance Imaging, Presented at Synposium on the 19th European society of magnetic resonance in medicine and biology, Cannes, France, Aug. 22-25, 2002.
  18. J. S. Jeng, T. H. Cheng and Y. M. Wang, Synthesis, Thermodynamic Stability and Relaxometric Characterization of Novel Gd(III) Complex with TTDASQ-protamine, Presented at Synposium on the Annual Meeting of Chinese Chemical Society, Taipei, Taiwan, R.O.C., Oct. 25-27, 2002.
  19. T. H. Cheng, J. S. Jeng and Y. M. Wang, Synthesis, Thermodynamic Stability and Relaxometric Characterization of the Novel [Gd(TTDASQ)] Complex, Presented at the 4th International Symposium for Chinese Inorganic Chemists, Hsinchu, Taiwan, R.O.C., Nov. 8-11, 2002.
  20. T. H. Cheng, M. H. Ou and Y. M. Wang, Design and Synthesis of a Novel Ligand 6-(2-Hydroxy-3,4-dioxo-1-cyclobutenyl)-3,6,10-triazadodecane-3,10-tetraacetic Acid (TTDASQ) for MRI Contrast Agent, Presented at the third international symposium for chinese medicinal chemists , Hong Kong., Dec. 28-31, 2002.

專利

  1. Wang YM, Liu G.C, Cheng TH, Wang YJ, Sheu R.S (2001) Bis(branched-alkyl derivative) amide for use as contrast agents in magnetic resonance imaging, ROC Patent No 135991.
  2. Wang YM, Liu G.C, Cheng TH, Lee WC, Sheu RS (2001) The derivatives of monopicolyl or mono(2-hydroxypropyl)triaminetetraacetic acid for use as contrast agents in magnetic resonance imaging, ROC Patent No 144352.

其他

校外專業服務

  1. 擔任聯群生技有限公司首席顧問(2004.8~至今)
  2. 擔任太冠瑪生物科技股份有限公司顧問(2016.12~至今)
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