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楊堉麟

教師一覽表

楊堉麟

學歷

高雄醫學大學 醫學技術學系畢業, 直升碩士 , 直升博士

高雄醫學大學 醫學研究所博士第一名畢業 (併獲年度博士優秀論文獎)

經歷

  1. 中華醫事科技大學生物科技系創系系主任 (91-96)
  2. 中華醫事科技大學生物安全委員會創始主任委員 (93-100)
  3. 中華醫事科技大學生物醫學研究所 創所暨籌備所長 (96)
  4. 高雄醫學大學醫學技術學系校友會會長 (96-98)
  5. 台南市與台南縣 SBIR計畫審查委員 (96-99)
  6. 中華醫事科技大學 學生事務處 學生事務長 (97-100)
  7. 中華醫事科技大學 生物科技系暨生物醫學研究所 教授 (97-100)
  8. 高雄醫學大學校友總會 創始理事 (97-100)
  9. 教育部南區區域教學資源中心委員 (97-100)

專長

腎臟科新陳代謝及內分泌，分子生物學，免疫學

教授課程

分子生物學及實驗 ，免疫學及實驗

證照

  1. 以臨床生化滿分成績取得 醫事檢驗師國家執照。發照單位：考選部。
  2. 特定化學物質作業主管證照。發照單位：中華民國工業安全衛生協會。
  3. 醫學實驗室認證規範ISO15189訓練合格證書。發照單位：財團法人全國認證基金會。
  4. TQC-OA 辦公室軟體應用類專案管理證照 (2010/11/25) 級別: 專業級 。
  5. TQC-DK 專業知識領域, 電子商務概論 專案管理證照 (2010/11/25) 級別: 專業級 。
  6. TQC-DK 專業知識領域, 專案管理概論 專案管理證照 (2010/05/28) 級別: 專業級 。
  7. 企業電子化助理規劃師。發照單位：財團法人中華民國電腦技能基金

執行計畫

歷年主持之專案研究計畫

  1. 探討胸腺基質淋巴生成素於糖尿病腎臟病變的角色與抗纖維化之臨床應用（NSC 99-2628-B-273 -001 -MY3）行政院國科會傑出學者養成計畫(個別型) 99/08/01 ～ 102/07/31 (國科會)   4,110,000元
  2. 大學實施頂尖人才彈性薪資申請計畫     100.1-102.7.31 (教育部) 1,800,000元
  3. 以免疫治療方式對抗腎纖維化之功效 (連宏生技股份有限公司)100/05/01-100/07/31 (產學合作計畫)       60,000元
  4. 活血中草藥發酵產物抗腎纖維化功效之開發 (貫閎開發生技股份有限公司)    100/01/01-100/05/31 (產學合作計畫)  60,000元
  5. 99年度南區區域教學資源中心計畫 (分項計畫三: 主持人)提升學生學習成效促進室性發展     99.2.1-100.6.30 (教育部) 約1,200,000元
  6. 100年度南區區域教學資源中心計畫 (分項計畫三: 主持人)找自己:全方位發展與學習輔導關懷計畫     100.7.1-101.6.30 (教育部)      2,449,040元
  7. 遞補學生事務與輔導人力計畫 (教育部)        99.1.1-99.12.31 4,771,750元
  8. 比較未分化與骨分化間質幹細胞對脊椎融合的效果。以膠原蛋白為載體的兔子實驗     (國科會共同主持人)      
  9. 遞補學生事務與輔導人力計畫 (教育部)        98.1.1-98.12.31 4,992,910元利用中草藥晶片技術針對特定天然物進行抗腎纖維化分析與TGF-beta/受器/受器後Smad相關路徑機轉探討（NSC 96-2314-B-273-002-MY3 ）(國科會)2007/08/01 ~ 2010/07/31       2,680,000 元
  10. 以活血中草藥杜牛膝分析抗纖維化有效成分（99B-17-036 ）(教育部園區產學合作計劃)     2010/01/25 ~ 2010/12/31 940,500 元 (MOE35, IND40)
  11. 以台灣血藤進行抗腎纖維化有效成分之專利開發 (98B-17-025) (國科會/教育部)     2009/01/01 ~ 2009/12/31   894,500 元
  12. 學界協助中小企業科技關懷計畫診斷計畫書(教育部/金屬中心) 2009/01/01 ~ 2009/6/31   30,000 元
  13. 建構中草藥活性活性成分篩選平台以提昇產業既有技術之經濟價值 (B-17-037)     2008/06/01 ~ 2009/01/31   897,000元
  14. 人類乳突病毒E2基因之研究  華產96 2008.1.1-2008.6.30    110,500
  15. 以生物晶片配合定量聚合酵素反應開發快速篩檢纖維化等疾病基因表現平台 華產96 2007.12.1-2008.5.31     133,900
  16. 探討第二型骨頭成型蛋白在糖尿病腎纖維化上治療的角色 NSC 95-2314-B273-003  814,000元
  17. 中草藥指標、有效成分與標準品之研究與開發 (衛生署)    CCMP95-TP-007 2006/5/26-2006/12/31     1342,000元
  18. 運用第二型血管加壓素抑制劑與第二型乙型轉型生長因子受器干擾性RNA之「雙重抑制策略」在糖尿病腎臟纖維化治療上之研究 NSC 94-2314-B273-001  816,000 元
  19. 探討TGF-beta R1/RII 與atypical PKC 對糖尿病腎病變之纖維化的角色
  20. NSC 93-2314-B273-001       1,020,000 元
  21. 探討CD36及受器後訊息傳導路徑在治療糖尿病腎病變之纖維化的角色
  22. NSC 92-2314-B273-001       650,000元
  23. 以轉錄因子誘餌探討逆轉高度糖化終產物所誘導腎臟細胞thrombospondin-1過量表現與細胞病變的可行性 NSC 91-2314-B-273 -005 1,020,000元
  24. 轉錄因子AP-1與NF-kappaB在高糖誘導腎小管細胞株之乙型轉型生長因子第二型受器表現所扮演的角色     NSC 90-2314-B-273-003 870,000元

其他政府機關相關研究計畫

衛生署 中醫藥委員會(CCMP)  中草藥指標、有效成分與標準品之研究與開發        CCMP95-TP-007 2006/5/26-2006/12/31  1342,000 元

發表著作

期刊論文

  1. Yu-Lin Yang (correspondance) #, Hong-Zen Ju, Shu-Fen Liu, Tao-Chen Lee, Yuan-Wei Shih, Lea-Yea Chuang, Jinn-Yuh Guh, Ya-Ying Yang, Tung-Nan Liao, Min-Yuan Hung. BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition. Journal of Cellular Biochemistry. Manuscript ID JCB-11-0070.R1 (2011, May 04) ACCEPTED
  2. Yu-Lin Yang et. al. (correspondance) The therapeutic Role of TSLP shRNA in treating pulmonary fibrosis. Molecular Therapy 19, sup 1, May 2011, S107-08 [With a 2008 impact factor of 5.970*, Molecular Therapy ranks 6/83 in the Medicine, Research & Experimental category of the 2008 Journal Citation Report, and in the top 5% of all science journals by Impact Factor]
  3. Lee TC, Wang CJ, Yang YL, Huang YH, Lin WC, Chang SY. Bone morphogenetic protein-2 expression in spinal fusion masses enhanced by extracorporeal shock wave treatment: a rabbit experiment.Acta Neurochir (Wien). (2010, Oct);152(10):1779-84.
  4. Ching-Jen Wang, M.D., Lin-Hsiu Weng, M.D., Shan-Ling Hsu, M.D., Yi-Chih Sun, B.S., Ya-Ju Yang, B.S., Yi-Sheng Chan, M.D., and Yu-Lin Yang, Ph.D (correspondance). pCMV–BMP-2–Transfected Cell– Mediated Gene Therapy in Anterior Cruciate Ligament Reconstruction in Rabbits. Arthroscopy: The Journal of Arthroscopic and Related Surgery, 26(7) : 968-976 (2010, July)
  5. Jeng-Hsien Yeh,Jenn-Kuen Lee,Jyh-Seng Wang,Mei-Yin Yeh,Yu-Lin Yang,Jau-Shyang Huang,Wen-Teng Chang,Daih-Huang Kuo,Pochuen Shieh,Fu-An Chen, Chun-Chi Kuo, and Chung-Ren Jan. Effect of Capsaicin on Ca21 Fluxes in Madin-Darby Canine Renal Tubular Cells. DRUG DEVELOPMENT RESEARCH 71(2) : 112–119 (2010, April)
  6. Liu Shu-Fen, Tao-Chen Lee, Jau-Shyang Huang, Li-Te Yin, Wen-Teng Chang, Yuan-Wei Shih, Lea-Yea Chuang, Jinn-Yuh Guh, Je-Luen Liang, Min-Yuan Hung, Yu-Lin Yang# (correspondance). Albumin induces mesangial cellular fibrosis by regulating type I TGF-β receptor and its downstream signal transducers [JDC-S-11-00082_Submitted 2011,April 5]
  7. Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by modulating catabolism of type I transforming growth factor-beta receptors. Chiang TA, Yang YL, Yang YY, Hu MH, Wu PF, Liu SF, Huang RM, Liao TN, Hung CY, Hung TJ, Lee TC. J Cell Biochem. 2010 Jan 20. [Epub ahead of print]PMID: 20091742
  8. Chen SC, Guh JY, Hwang CC, Chiou SJ, Lin TD, Ko YM, Huang JS, Yang YL, Chuang LY. J Cell Biochem. 2010 Jan 1;109(1):38-48. Advanced glycation end-products activate extracellular signal-regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts.
  9. Yang YL (Corresponding author), Liu YS, Chuang LY, Guh JY, Lee TC, Liao TN, Hung MY, Chiang TA. Endocrinology. 2009 Feb;150(2):727-40. PMID: 18832104. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. (SCI: 5.23)
  10. Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model. Lee TC, Chang NK, Su FW, Yang YL, Su TM, Lin YJ, Lin WC, Huang HY. Surg Neurol. 2009 Dec;72 Suppl 2:S75-9; discussion S79. Epub 2009 Aug 7.PMID: 19665194
  11. Biomechanical testing of spinal fusion segments enhanced by extracorporeal shock wave treatment in rabbits. Lee TC, Yang YL, Chang NK, Lin TS, LinWC, Liu YS,Wang CJ.Chang Gung Med J. 2009 May-Jun;32(3):276-82.PMID: 19527606
  12. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Huang JS, Chuang LY, Guh JY, Yang YL, Hsu MS. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):220-6. Epub 2008 Sep 12.PMID: 18834896
  13. Application of extracorporeal shock wave treatment to enhance spinal fusion: a rabbit experiment. Lee TC, Huang HY, Yang YL, Hung KS, Cheng CH, Lin WC, Wang CJ. Surg Neurol. 2008 Aug;70(2):129-34; discussion 134.PMID: 18640400
  14. Yang YL (Corresponding author),*, Chang SY, Teng HC, Liu YS, Lee TC, Chuang LY, Guh JY, Chang FR, Liao TN, Huang JS, Yeh JH, Chang WT, Hung MY, Wang CJ, Chiang TA, Hung CY, Hung TJ. Safflower extract: A novel renal fibrosis antagonist that functions by suppressing autocrine TGF-beta. J Cell Biochem. 2008 Jan 11; [Epub ahead of print] PMID: 18189272 [SCI 3.409] .
  15. Wang HC, Yang YL, Lin WC, ChenWF, Yang TM, Lin YJ, Rau CS, Lee TC. Computer- assisted pedicle screw placement for thoracolumbar spine fracture with separate spinal reference clamp placement and registration. Surg Neurol. 2008 Jan 17; PMID: 18207531 [SCI 1.057]
  16. ChouWW, Guh JY, Tsai JF, Hwang CC, Chen HC, Huang JS, Yang YL, HungWC, Chuang LY. Arecoline-induced growth arrest and p21(WAF1) expression are dependent on p53 in rat hepatocytes. Toxicology. 2008 Jan 14;243(1-2):1-10. Epub 2007 Sep 8. PMID: 17997002 [SCI 2.685]
  17. Yang YL (Corresponding author), Lin SH, Chuang LY, Guh JY, Liao TN, Lee TC, ChangWT, Chang FR, Hung MY, Chiang TA, Hung CY. CD36 is a novel and potential anti-fibrogenic target in albumin-induced renal proximal tubule fibrosis. J Cell Biochem. 2007 Jun 1;101(3):735-44. PMID: 17226761 [SCI 3.409]
  18. Lee TC, Huang HY, Yang YL, Hung KS, Cheng CH, Chang NK, Chung YH, Hu MS,Wang CJ. Vulnerability of the spinal cord to injury from extracorporeal shock waves in rabbits. J Clin Neurosci. 2007 Sep;14(9):873-8. PMID: 17660057 [SCI 0.673]
  19. Chen YH, Guh JY, Chuang TD, Chen HC, Chiou SJ, Huang JS, Yang YL, Chuang LY. High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. Arch Biochem Biophys. 2007 Jun 4; PMID: 17597576 [SCI 2.969]
  20. Chen SC, Guh JY, Chen HC, Yang YL, Huang JS, Chuang LY. Advanced glycation end-product-induced mitogenesis is dependent on Janus kinase 2-induced heat shock protein 70 in normal rat kidney interstitial fibroblast cells. Transl Res. 2007 May;149(5):274-81. PMID: 17466927 [PubMed - in process] [SCI]
  21. Chuang TD, Guh JY, Chiou SJ, Chen HC, Huang JS, Yang YL, Chuang LY. Phosphoinositide 3-kinase is required for high glucose-induced hypertrophy and p21WAF1 expression in LLC-PK1 cells. Kidney Int. 2007 May;71(9):867-74. Epub 2007 Feb 28. PMID: 17332736 [SCI 4.773]
  22. Lee TC, Ho JT, Hung KS, ChenWF, Chung YH, Yang YL* (Corresponding author). Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment. Neurosurgery. 2006 Feb;58(2):373-80; discussion 373-80 [SCI 2.692]
  23. Liu HC, Liao TN, Lee TC, Chuang LY, Guh JY, Liu SF, Hu MS, Yang YL, Lin SH, Hung MY, Huang JS, Hung TJ, Chen CD, Chiang TA, Chan JY, Chen SY, Yang YL* (Corresponding author). Albumin induces cellular fibrosis by upregulating transforming growth factor-beta ligand and its receptors in renal distal tubule cells. J Cell Biochem. 2006 Apr 1;97(5):956-68. PMID: 16267840 [SCI 3.409]
  24. Yeh JH, Cheng HH, Huang CJ, Chung HM, Chiu HF, Yang YL, Yeh MY, ChenWC, Kao CH, Chou CT, Jan CR. Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):416-22. PMID: 16623868 [SCI 1.788]
  25. Huang JS, Chuang LY, Guh JY, Chen CJ, Yang YL, Chiang TA, Hung MY, Liao TN. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts. J Am Soc Nephrol. 2005 Aug;16(8):2318-29. Epub 2005 Jun 15. PMID: 15958724 [SCI 7.371]
  26. Lee CI, Guh JY, Chen HC, HungWC, Yang YL, Chuang LY. Advanced glycation end-product-induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK-49F cells. J Cell Biochem. 2005 May 15;95(2):281-92. PMID: 15770649 [SCI 3.409]
  27. Yang YL (Corresponding author), Chuang LY, Guh JY, Liu SF, Hung MY, Liao TN, Huang YL. Thrombospondin-1 mediates distal tubule hypertrophy induced by glycated albumin. Biochem J. 2004 Apr 1;379(Pt 1):89-97. PMID: 14683523 [SCI 4.100]
  28. Lee CI, Guh JY, Chen HC, Lin KH, Yang YL, HungWC, Lai YH, Chuang LY. Leptin and connective tissue growth factor in advanced glycation end-product-induced effects in NRK-49F cells. J Cell Biochem. 2004 Nov 15; 93(5):940-50. PMID: 15389880 [SCI 3.409]
  29. Chuang LY, Guh JY, Liu SF, Hung MY, Liao TN, Chiang TA, Huang JS, Huang YL, Lin CF, Yang YL* (Corresponding author) Regulation of type II transforming-growth-factor -beta receptors by protein kinase C iota. Biochem J. 2003 Oct 15;375(Pt 2):385-93. PMID: 12841849 [SCI 4.100]
  30. Yang YL, Guh JY, Yang ML, Lai YH, Tsai JH, HungWC, Chang CC, Chuang LY. Interaction between high glucose and TGF-beta in cell cycle protein regulations in MDCK cells.J Am Soc Nephrol. 1998 Feb;9(2):182-93. PMID: 9527394 [SCI 7.371]
  31. Yang ML, Guh JY, Yang YL, Chang CC, Chuang LY. Captopril reverses high glucose-induced effects on LLC-PK1 cells partly by enhancing facilitative glucose transporter messenger RNA expressions. Biochem Mol Biol Int. 1997 Mar;41(3):511-9. PMID: 9090458 [SCI]
  32. Yang ML, Guh JY, Lai YH, Yang YL, Chang CC, Tsai JH, Chuang LY. Effects of high glucose culture on EGF effects and EGF receptors in the LLC-PK1 cells. Am J Nephrol. 1997;17(2):193-8. PMID:9096453 [SCI 2.879]
  33. Guh JY, Yang ML, Yang YL, Chang CC, Chuang LY. Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-beta receptor protein expressions. J Am Soc Nephrol. 1996 Aug;7(8):1207-15. PMID: 8866414 [SCI 7.371]

研討會論文：五年內國內學術研討會之論文計25 篇

2006 年21 屆生醫年會

  1. CAPTOPRIL INDUCES A DECREASE IN TGF-BETA RECEPTOR VIA THE SECRETION OF BMP-2 IN RENAL CELLS.

Chun-Yu Chen1*, Sen-Yi Chen1, Tung-Nan Liao2,Lea-Yea Chuang3,Jinn-Yuh Guh4,Shu-Fen Liu4,Min-Yuan Hung5,Yu-Lin Yang1#

  1. BMP-2 ATTENUATES BETA-HYDROXYBUTYATE (-HB)-INDUCED INCREASE IN TYPE I RECEPTORS OF TGF-1 IN RENAL FIBROBLAST CELLS

Chun-YuChen1*,Sen-YiChen1,Tung-NanLiao2,Lea-YeaChuang3,Jinn-YuhGuh4,Shu-FenLiu4,Min-Yuan Hung5,Yu-Lin Yang1#

  1. GLUCOSE INDUCED BMP-2 EXPRESSION IN NORMAL RAT FIBROBLAST CELLS

Yu-Shun Chuang1, Tung-Nan Liao2, Lea -Yea Chuang3, Jinn-Yuh Guh4, Shu –Fen Liu4, Min-Yuan Hung5, Yu-Lin Yang1#

  1. PI3 KINASE AND PGC-1 REGULATE THE EXPRESSION OF TRANSCRIPTION FACTOR NRF-1 DOWNSTREAM GENE IAP/CD47

Chen-Yin Yu1*, Sung-Tzu Tsau1*, A-Min Huang2, Yu-Lin Yang1, Wen-Teng Chang1#

2007 年22 屆生醫年會

  1.  BMP-2 TRANSMITS FIBROGENESIS ANTAGONIZINGSIGNALS BY TRANSACTIVATING THREE TRANSCRIPTIONAL FACTORS IN RENAL FBROBLAST CELLS

Yi-Shiuan Liu1,5*, Tao-Chen Lee2, Tung-Nan Liao3,5, Jinn-Yuh Guh4, Shu –Fen Liu4, Min-Yuan Hung5,Ko-Tseng Liu1, Yu-Lin Yang1,5#

  1. ELUCID ATIONOF RENAL FIBROSIS INHIBITORY EFFECTS FROM BLOODCIRCULATION PROMOTING CHINESE HERBS

Shan-Yu Chang1*, Hsiang-Chun Teng1*, Tung-Nan Liao2, Fang-Rong Chang3, Lea -Yea Chuang4, Shu -Fen Liu5, Min-Yuan Hung6, Yu-Lin Yang1#

  1. EFFECTS OF BONE MORPHOGEETIC PROTEIN 2 ON THE EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I IN MESANGIAL CELLS UNDER DISTINCT DIABETIC CONDITIONS

Yi-Shiang Yang1*, Yi-Miao Lin1, Hong-Jie Zeng1, Jian-Yong Lin1, Tung-Nan Liao2, Shu -Fen Liu3, Min-Yuan Hung4, Yu-Lin Yang1#

  1. THE POLYMORPHISMS OF CYP2A13 AMONG TAIWAN LUNG CANCER PATIENTS

Yi-Chun Lin1*, Ya-Yang Yang1, Jin-Shun Shu1, Si-Yin Guo1, Yu-Lin Yang1, Min-Yuan Hung1, Tai-An Chiang1#

  1. TO ELUCIDATE THE ANTI-FIBROSIS MECHANISM OF CHINESE HERB, DIOSCOREA ALATA

Wen-Shan Lin1*, Si-Jia Huang1*, Fang-Rong Chang2, Ho-Shin Huang3, Tung-Nan Liao4, Tai-An Chiang5, Min-Yuan Hung5, Yu-Lin Yang1#

2008 年23 屆生醫年會

  1. Bone Morphogenetic Protein (BMP)-2 Reversed the Epithelial-to-Mesenchymal Transition by Enhancing E-cadherin Expression in Renal Interstitial Fibroblasts.

Meng-Sheng Lee1*, Yi-Shiuan Liu2, Tung-Nan Liao3, Lea -Yea Chuang4, Fang-Rong Chang5, Shu –Fen Liu6, Min-Yuan Hung2, Tai-An Chiang2#, Yu-Lin Yang1,7

  1. Hyperosmolarity enhanced the fibrosis susceptibility by phosphorylation of type II TGF-β receptors and up-regulation of Tbeta-RI in MDCK cells.

Ya-Yang Yang1,5*, Tai-An Chiang1, Yi-Shiuan Liu1,5, Min-Yuan Hung1, Lea -Yea Chuang2, Jinn-Yuh Guh3, Fang-Rong Chang4, Shu-Fen Liu3, Yu-Lin Yang5,6#

  1. Nuclear Respiratory Factor (NRF) -1 suppressed fibrogenic signal cascade by increasing Smad7 expression and reducing the expression of TGF-beta receptors

Je-Luen Liang 1,2*, Yi-Shiuan Liu1,2, Tung-Nan Liao3, Lea-Yea Chuang4, Fang-Rong

Chang5, Shu-Fen Liu6, Min-Yuan Hung1, Tai-An Chiang1, Yu-Lin Yang2,7

  1. Bovine Serum Albumin Enhance Fibrotic Sensitivity by Decreasing Ubiquitination of Type I Receptors of Transforming Growth Factor-beta

Yi-Shiang Yang1*, Hong-Jie Zeng1, Yu-Lin Yang1#

  1. Bone Morphogenetic Protein (BMP)-2 Antagonizes TGF-β induced Renal Cellular Fibrosis by Promoting Catabolism of Type I TGF-b Receptors

Yi-Shiuan Liu1,5*, Tao-Chen Lee2, Tung-Nan Liao3,5, Jinn-Yuh Guh4, Shu –Fen Liu4, Min-Yuan Hung5, Ko-Tseng Liu1, Yu-Lin Yang1,5#

2009 年24 屆生醫年會

  1. BMP-2 suppress TGF-β-induced renal cellular fibrosis by down-regulating the expression of TSLP

Guo-ZhengLiu1*, Tai-AnChiang1,2, Tsung-JenHung3, Lea-YeaChuang4, Tung-NanLiao1,2, Min-Yuan Hung1,2, Ya-Yang Yang1, Yu-Lin Yang5,6#

  1. Hyperosmolarity enhanced the fibrosis susceptibility by phosphorylation of type II TGF-β receptors and up-regulation of Tbeta-RI in MDCK cells

Ya-Yang Yang1*, Tai-An Chiang1, Lea -Yea Chuang2, Tung-Nan Liao1, Min-Yuan Hung1, Yu-Lin Yang3#

  1. BMP-2 suppresses TGF-β-induced renal fibrosis by regulating epithelial-mesenchymal transition (EMT) process.

Hong-Zen Ju1,2*, Mon-Shen Li2, Lea -Yea Chuang3, Tung-Nan Liao4,5, Min-Yuan Hung5, Tai-An Chiang5, Yu-Lin Yang1,2#

  1. Dioscorea alata L. reverses β-HB-induced renal interstitial fibrosis by inhibiting TGF-β/smad signaling pathway.

Shan-Yu Chang 1,2*, Wen-Shan Lin3, Tao-Chen Lee4, Lea-Yea Chuang5, Tung-Nan Liao6,7, Min-Yuan Hung6, Tai-An Chiang6, Yu-Lin Yang1,2#

  1. Bovine Serum Albumin Enhance Fibrotic Sensitivity by Increasing Half-life of Type I TGF-β Receptors.

Je-Luen Liang1,2*, Yi-Shiang Yang1, Lea -Yea Chuang3, Tung-Nan Liao2,4, Min-Yuan Hung2, Tai-An Chiang2, Yu-Lin Yang1,5#

  1. Bovine Serum Albumin Enhance Growth Arrest by regulating MAPK Signaling and p21/p27.

Je-Luen Liang1,2*, Yi-Shiang Yang1, Lea -Yea Chuang3, Tung-Nan Liao2,4, Min-Yuan Hung2, Tai-An Chiang2, Yu-Lin Yang1,5#

2010 年25 屆生醫年會

  1. Radix Achyranthis Bidentatae regulates cellular fibrosis in mouse glomerular mesangial cells

Ya Ying Yang 1,2, Shu-Fen Liu 3 Tao-Chen Lee4, Lea -Yea Chuang5, Tung-Nan Liao6,7, Min-Yuan Hung1,2, Guo-Zheng Liu1,2,Yu-Lin Yang1,2#

  1. TGF-beta induces cellular fibrosis in renal and lung by regulating thymic stromal lymphopoietin

Guo-Zheng Liu1,, Yu-Lin Yang1,2, Tai-An Chiang1,2, Shu-fen Liu 3, Tung-Nan Liao1,2, Min-Yuan Hung1,2, Ya-Yang Yang1, Tsung-Jen Hung3#

  1. Dioscorea alata L. reverses renal interstitial fibrosis by regulating smad- and EMT related signaling pathway

Shan-Yu Chang1,2*, Shu-fen Liu3, Tao-Chen Lee4, Lea-Yea Chuang5, Tung-Nan Liao6,7, Min-Yuan Hung6, Wen-Teng Chang1,2, Yu-Lin Yang1,2#

  1. BMP-2 Suppresses TGF-β-Induced Renal Fibrosis by Regulating Epithelial-Mesenchymal Transition and Snail

Hong-Zen Ju1,2*, Lea -Yea Chuang3, Shu-Fen Liu 7, Tao-Chen Lee6 , Tung-Nan Liao4,5, Min- Yuan Hung5, Yu-Lin Yang1,2#

  1. The anti-fibrosis effect of herbal extracts on renal interstitial fibroblasts

Shyh-Horng Lin1*, Mei-Fen Chen3, Shu-Fen Liu2, Lea-Yea Chuan2, Yu-Lin Yang3#

2011 年26 屆生醫年會

  1. 20-Hydroxyecdysone Attenuates TGF-β1-induced Renal Cellular Fibrosis in Proximal Tubule Cells

Wei-Ming Chen1*, Su-Fen Liu2, Tao-Chen Lee3, Lea-Yea Chuang4, Min-Yuan Hung5, Yu-Lin Yang1,5#

  1. The Role of Interleukin-7 in Attenuating Renal Cellular Fibrosis

Pei-fang Hsieh1*, Su-Fen Liu2, Tao-Chen Lee3, Jau-Shyang Huang1, Li-Te Yin1, Wen-Teng Chang1, Lea-Yea Chuang4, Jinn-Yuh Guh2, Min-Yuan Hung5, Yu-Lin Yang1,5#

  1. Study on the Anti-fibrosis Effect of Herb Extract in Human Lung Fibroblasts Cells

Chien-Ya Hung1, Shu-Jhen Ma2*, Tsung-Jen Hung3, Su-Fen Liu4, Tao-Chen Lee5, Jeng-Hsien Yeh6, Yih-Min Sun7, Min-Yuan Hung2, Jau-Shyang Huang3, Li-Te Yin3, Wen-Teng Chang3, Yu-Lin Yang2,3#

  1. Fermentation with herbal active extract reversed renal interstitial fibrosis in renal fibroblast cells

Ya-Yang Yang1*, Su-Fen Liu2, Yih-Min Sun3, Tao-Chen Lee4, Lea-Yea Chuang5, Jinn-Yuh Guh2, Min-Yuan Hung6, Tsung-Jen Hung7, Chien-Ya HungMi8, Ming-Chuan Hong9, Mei-Fen Chen10, Yu-Lin Yang1,6#

  1. Using cytokine-derived shRNA as a therapeutic tool for treating pulmonary fibrosis

Tsung-Jen Hung1*, Guo-Zheng Liu2, Su-Fen Liu3, Tao-Chen Lee4, Zih-Han Yang2, Lea-Yea Chuang5, Jinn-Yuh Guh3, Tung-Nan Liao6, Min-Yuan Hung6, Yu-Lin Yang2,6#

  1. Effect of Probiotic on Transforming Growth Factor β-1-induced Fibrosis in Rat Hepatic Stellate Cells

Zih-Han Yang1*, Su-Fen Liu3, Tao-Chen Lee4, Min-Yuan Hung5, Yih-Min Sun6, Jau-Shyang Huang2, Li-Te Yin2, Wen-Teng Chang2, Yu-Lin Yang2,5#

國際神經再生協會（94 年）

THE EFFECT OF CONTROL RELEASE WITH FIBRIN GEL IN SPINAL FUSION USING RAT KIDNEY CELLS TRANSFECTED WITH BONE MORPHOGENETIC PROTEIN GENE. A RABBIT EXPERIMENT. (Yu-Lin Yang 第三作者),

專書

YU-LIN YANG , WEN- TENG CHANG AND YUAN-WEI SHIH, "GENE THERAPY, CHAPTER TITLE: GENE THERAPY USING RNAI".  INTECH (OPEN ACCESS PUBLISHER) [ISBN: 978-953-307-240-1] (2011)

專利

  1. 99146093     王不留行       發明專利        2010/12/27
  2. 100209225   可自行控制長度的微量分注器    新型專利        2011/5/23
  3. 100132736   蛻皮激素作為藥物治療組織纖維化    發明專利        2011-09-09
  4. 100132738   Interleukin 7抑制腎纖維化之應用       發明專利        2011-09-09
  5. 201100089   2011/01/01      使用山藥植物之經水萃取的產物來治療糖尿病腎病變    發明專利
  6. M413091     2011/10/01      雙開口酒精    新型專利

專案技術轉移執行成效

  1. 編號:10001001    以北蟲草萃取液對抗腎纖維治療之開發    欣潤生物科技股份有限公司        100年1月1日至100年10月31日
  2. 編號:10001002    開發酵素對抗腎纖維治療之平台        貫閎開發生技股份有限公司        100年1月1日至100年10月31日
  3. 編號:10001003    以免疫生長因子開發腎纖維化控制技        啟瀚科技有限公司        100年6月1日至100年12月1日
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